Aboriginal and Torres Strait Islander people experience significant disparities and inequities in access to care and in health outcomes across Australia. These disparities are most marked in socio-economically disadvantaged regions, particularly in remote Northern and Central Australia. Social determinants of health including poverty, racism, intergenerational trauma and impacts of colonisation continue to contribute to health inequities experienced by Aboriginal and Torres Strait Islander people. Rates of pre-existing type 2 diabetes in pregnancy are ten times higher among Aboriginal and Torres Strait Islander women than non-Indigenous women. These high rates of young-onset chronic conditions such as type 2 diabetes contribute to disparities in birth outcomes for Aboriginal and Torres Strait Islander women compared to non-Indigenous women, including higher rates of premature birth, large for gestational age and admission to higher level care. Our Diabetes across the Lifecourse: Northern Australian Partnership’s vision is to work in partnership with Aboriginal and Torres Strait Islander people, primary health care and community-controlled organisations to break the intergenerational cycle of type 2 diabetes and related conditions. Our implementation science work with health service providers has led to policy and practice improvements in antenatal and inter-pregnancy care of women with gestational diabetes and women with type 2 diabetes. Our current work with Aboriginal communities involves co-design of community-based approaches to reduce diabetes-related risks before, during and after a pregnancy with diabetes. Although telehealth plays an increasing role in our clinical work in a post-COVID world, community-based relationships and partnerships remain critical to improving health outcomes. Working in true partnership with Aboriginal and Torres Strait Islander people, communities and community-controlled organisations, we aim to reduce disparities and inequities in health outcomes.